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Evidence Boundaries Consumers should understand the distinction between ingredient-level evidence and product-level evidence when evaluating any compounded GLP-1 offering

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Notably, currently approved GLP-1RAs such as semaglutide, exenatide, dulaglutide, and liraglutide are known to cross the bloodbrain barrier (BBB), thereby gaining access to the CNS [39,40]

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1 2 Annals of Internal Medicine