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The tolerability profile is slightly better than Semaglutide, with lower rates of nausea (25% vs 44%) and vomiting (10% vs 24%)

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They sit near the top of the evidence hierarchy, just below meta-analyses (which combine multiple RCTs)

Any of these warrant rechecking your calculation and potentially reducing the dose

Current status Ozempic : FDA approved for adults with type 2 diabetes Wegovy : semaglutide product FDA approved for chronic weight management in eligible patients Retatrutide : not FDA approved as of March 25, 2026 FDA has also warned consumers about illegally sold unapproved GLP-1-related products containing retatrutide

Furthermore, it was not possible to retrieve data on the incidence of cancer from one large trial with liraglutide, 68 although the analysis of funnel plots did not suggest selective reporting