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High doses of trans-RES significantly mitigated these changes, suggesting an overall improvement in neuroendocrine function

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Their impact on thyroid homeostasis is multifaceted: they regulate hormone synthesis, metabolism, and immune activity, with dysregulation linked to thyrotoxicosis, hypothyroidism, AITD (Graves disease and Hashimotos thyroiditis), and thyroid malignancies (12)

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In a three-month study with 58 hypertensive patients, taking the anti-hypertensive drug nifedipine (a calcium channel blocker), the plasma levels of vasoconstrictor molecule endothelin-1 were significantly lowered by 9% after one month and by 16% after three months in the group taking 100 mg Pycnogenol compared to the placebo group ( compared to the placebo group

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