Severe constipation typically improves with lifestyle modifications and gentle medications before dose reduction becomes necessary
Additionally, the presence of publication bias suggested by Eggers test and funnel plot asymmetry indicates that smaller studies with non-significant results might be underrepresented
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Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimers disease
In the intrinsic pathway, oxidative stress or GSH depletion induces BAX SSG at Cys62, promoting its mitochondrial translocation and subsequent activation of CASP9 and CASP3 44
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