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The skin gradually returns to its natural pigmentation over time
PMID: 2706459
The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)
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Blood levels of P1NP (procollagen type I N-terminal propeptide), a marker of bone formation, also increased significantly, while markers of bone degradation decreased
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