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The c-Jun NH(2)-terminal protein kinases (JNK) 1 and 2 and glycogen synthase kinase 3 alpha and 3 beta (GSK-3alpha and -3beta) are the negative regulators of GSH synthesis, since their upregulation affects Nrf2 activation and the expression of -glutamylcysteine synthase which results in decreased GSH level [108]

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31, e1902900

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