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In BMAL1-knockout mice, pericytes progressively detach, extracellular matrix deposition is reduced, and tight junctions disassemble, leading to unstable neovasculature and loss of BBB integrity (79)

Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

The higher concentration means smaller injection volumes, which some researchers prefer

Through these mechanisms, adiponectin contributes to improved insulin-induced signal transduction, and hence improved insulin sensitivity (Yamauchi et al., 2001)