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Acknowledgements This work was supported by the National Institutes of Health (R01 GM056414, to S.H.G.)

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Consequently, GLP-1 RAs reduce blood glucose and glycated hemoglobin levels, facilitating weight loss and improving blood pressure and lipid profile in T2D patients

Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Figure 2, this novel senolytic did remove cells from the PDL9 chondrocytes, which was accompanied by significantly reduced levels of SA--gal staining

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15 DHA also caused replication stress, apoptosis, autophagy, and lysosomal stress, suggesting a hybrid cell death mechanism