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The gene encoding this enzyme is polymorphic, with one major variants of relevance to alcohol toxicity (see table below): The atypical ALDH2*2 enzyme metabolizes acetaldehyde very slowly

Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo

JAMA 305(21):2173-2174

To shorten the description, the use of NADPH at several concentrations is not described here, but was performed by the same statistical methods of analysis previously described for GP

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