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Body Composition Changes During Weight Reduction With Tirzepatide in the SURMOUNT-1 Study of Adults With Obesity or Overweight

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65 Interaction with the TAD domain of site-specific transcription factors, mediates the positioning of the transcriptional co-activators at promoter regions, 66 where they induce chromatin remodeling and act as bridges between general transcription machinery and the activator, hence promoting transcription activation