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4d), lower total fat (Fig

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Importantly, tesofensine reduces daily food intake by approximately 49% during the initial treatment period, demonstrating powerful appetite suppression that drives the observed weight loss

Her fasting insulin was elevated and her resting metabolic rate was 340 calories below the Harris-Benedict estimate, which meant every calorie target she had been given was wrong

Third, both the rates of, and factors associated with, treatment discontinuation were similar for GLP-1 receptor agonists and SGLT2 inhibitors, indicating that patient-specific factors, rather than drug-specific factors (such as side-effects), are driving treatment discontinuation