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Joint mobility increases, inflammation decreases noticeably, and tissue quality improves as measured by reduced swelling and improved palpation findings

Research Limitations Current evidence has limitations

A 2015 Cell Metabolism study that first characterized MOTS-c as a mitochondria-derived regulator of metabolic homeostasis capable of reducing obesity and insulin resistance in animal models was foundational in establishing this peptide class

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But it doesnt seem to be very common

For those at risk, like vegetarians or older adults, vitamin B12 supplement can be helpful