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4 Necroptosis in CP-induced acute kidney injury (AKI) 4.1 Fundamentals of necroptosis 4.1.1 General overview of necroptosis The term programmed cell death had been commonly used to describe caspase-dependent apoptosis until caspase-independent necrosis was identified (Linkermann et al., 2012)

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It activates the MAPK/ERK signaling pathway, which tells fibroblasts (the cells that produce collagen) to ramp up production

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To determine whether the effect of H 2 O 2 on axonal fusion is mediated by lipid peroxidation, we applied H 2 O 2 and Fer-1 simultaneously and examined if blocking lipid peroxidation could block H 2 O 2 -induced axonal fusion