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More than four in ten Americans (43%) cite issues such as "Ozempic face," hollowed features, or sagging skin as a reason they would not take a GLP-1, even if recommended by their doctor

There have been no large-scale studies on humans, and its role as a clinical therapy is considered scientifically controversial

Medical News Today, 2026

It can also be prescribed to lower the risk of major cardiovascular problems (e.g., heart attack, stroke) in adults with heart disease and obesity or overweight, even without type 2 diabetes

Fortier, L

Wolf J, Seto T, Han J-Y, Reguart N, Garon EB, Groen HJM, Tan DSW, Hida T, de Jonge M, Orlov SV, et al