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When taken orally, these liposomes arrive at the intestinal wall and fuse with the membranes of the cells that line the intestine (see figure 1)

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Furthermore, pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia, both associated with pancreatic cancer development, express GLP-1R, while normal pancreatic ductal cells and acini demonstrate proliferative responses to GLP-1RAs, suggesting that incretin-based medications may induce specific proliferative changes in the islets

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