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Same 30 year old lady with varicose veins - side view

Such alterations have been noted in individuals with type 2 diabetes, obesity, and metabolic syndrome, though the precise mechanisms remain an active area of research

The Phase 2 trial also included a meta-analysis benchmark: a 2025 systematic review and meta-analysis of 3 RCTs involving 878 patients found a mean body weight reduction of 14.33% versus placebo, with a BMI reduction of 5.38 and waist circumference reduction of 10.51 cm

It usually manifests on the back and outer sides of the arms

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