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There is no good evidence for this, and it is worth being cautious about that framing

FDA ADVISORY committee meeting

As of April 22, 2026, it was removed from FDA Category 2, but the FDA's Pharmacy Compounding Advisory Committee will not consider it for the 503A bulks list until the July 23, 2026 meeting

However, for most people with normal B12 levels, supplementation or injections do not significantly affect metabolism or fat loss

This is most relevant when vitamin B12 deficiency is being corrected and broader B-vitamin support is clinically appropriate, where symptoms include a combination of fatigue, neurological features, and stress, or where rapid repletion and functional support are desired

Vitamin B12, B6, B complex, Lipotropic Injections and more