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Tirzepatide: dual GIP/GLP-1 receptor agonism Tirzepatide demonstrated that dual incretin receptor agonism could produce greater weight loss than earlier single-receptor approaches

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In the SURMOUNT-1 trial, patients lost an average of 15-21% of their initial body weight over 72 weeks, with results varying by dose and individual factors

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Moreover, low plasma concentrations of SELENOP have been associated with increased risk of heart failure in a recent population-based, prospective cohort study (16)