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Nat Commun 11 , 3326 (2020)

The other pathway that can affect homocysteine levels is the transsulfuration pathway, which leads to the synthesis of taurine

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The included research encompasses both large-sample, long-term follow-up real-world databases and rigorously designed double-blind controlled trials, ensuring a diversity of study types and a rich hierarchy of evidence

J.GodlewskaB

found that the ratio of GSH/GSSG in chondrocytes in elderly patients (age 50) is lower than the ratio of GSH/GSSG in chondrocytes in young patients (age 1849), suggesting that oxidative stress increases with age, which increases the risk of oxidant-mediated cell death in chondrocytes through the imbalance of the glutathione antioxidant system (Carlo and Loeser, 2003)