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Some medicines may reduce the effectiveness of the oral contraceptive pill, particularly if they cause vomiting or diarrhoea, so an alternative or additional method of contraception may be needed

For instance, a 45-year-old with mild androgen decline and no comorbidities might tolerate transient mood symptoms in exchange for enhanced sperm quality

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In clinical trials, diarrhea was reported as the third most common side effect in about 8% of people taking the medication