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Most patients notice meaningful appetite reduction within 1-2 weeks, but the strongest effects typically emerge around week 3-4 when steady-state medication levels are reached

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In this regard, studies on the effect of pasteurization on melatonin levels in breast milk have reported conflicting results, with one study of 18 samples finding no change [75], while another study of 10 samples observed a significant decrease [76]

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DOI: 10.1016/j.anireprosci.2025.107871