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When it comes to the delivery of GLP-1 gene, the following strategies have been developed so far: viral vectors, peptide-antibody constructs, formation of polyplexes using polyethyleneimine (PEI), arginine-based polymers, chitosan-based complexes, protamine-based complexes, and complexes based on protamine and bile salts

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According to NICE guidance (NG28), GLP-1 receptor agonists like Ozempic are typically considered when triple therapy is ineffective, not tolerated or contraindicated, with specific BMI and clinical criteria

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doi: 10.1038/s41514-023-00124-2