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Across GLP-1 trials, roughly 60% of lost weight returns within a year and about 75% over the longer regain curve. Lower-dose maintenance has stronger evidence than complete withdrawal

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Detection times may depend on the type of drug, how much the person takes, and how fast their metabolism works

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As summarized in the same 2013 review, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, even as the safety and tolerability picture held [7]