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35 An example of this prophylactic treatment of near-threshold retinopathy would be to initiate intravitreal anti-vascular endothelial growth factor therapy for central macular edema that does not meet criteria for CI-DME rather than observing

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however, interestingly, these patients do not manifest major clinical symptoms, most likely due to the compensatory effect of other antioxidant enzymes possessing catalase-like activity

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