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In this context, the REWIND trial (dulaglutide) stands out as a notable exception: with over 46% female participants, it offered a rare opportunity to explore efficacy and safety across sexes more robustly

Copy number alterations (CNAs), including deletions of the CDKN2A tumour suppressor and amplifications of BRAF , arise infrequently in nevi but are more abundant in invasive melanoma 6,14

Individuals who are pregnant or breastfeeding, have certain medical conditions, or have a history of adverse reactions to weight loss medications may not qualify

This means DSIP should begin to work rapidly once administered [24]

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