The compound patent, U.S
Persistent severe constipation or diarrhea (Bristol Stool Chart types 1 or 2, or 6 or 7) Blood in the stool or black, tarry stools Excessive mucus in the stool Persistent changes in bowel habits (such as chronic constipation or diarrhea) Very foul-smelling stools Sudden, significant changes in stool appearance or frequency Pencil-thin or ribbon-like stools (could suggest narrowing of the colon) Associated symptoms like abdominal pain, distended belly, rectal pain, nausea or vomiting, bloating, or unexplained weight loss If you experience any of these symptoms, or if your stool consistently falls outside the ideal type 3 to 4 range without an obvious dietary or lifestyle cause, you should consult a gastroenterologist for further evaluation, says Patel
While approved for safety and efficacy, ongoing monitoring and communication with healthcare providers are essential
This temporal specificity minimizes systemic effects while maximizing therapeutic drug delivery
In the OASIS 4 trial, nausea lasted on average less than two weeks and vomiting lasted a few days at each dose level
Consult the doctor if you experience any undesirable side effects
