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Growth hormone exerts both direct and indirect effects on bone metabolism through actions on osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells), while IGF-1 serves as a primary mediator of growth hormone's anabolic effects on skeletal tissue

Deducing from the above findings, it can be suggested that hypertension, obesity, insulin resistance, certain mental disorder and prolonged ejaculatory abstinence period impairs male fertility through increase in the formation of ROS and a subsequent decrease in antioxidant activities, which consequently lead to OS

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Liao Y, Smyth GK, Shi W