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In the STEP8 trial, comparing semaglutide (2.4 mg, weekly subcutaneous injection) with liraglutide (3.0 mg, daily subcutaneous injection) in patients with overweight or obesity and no previous bariatric surgery or T2D, a mean weight change from baseline of 15.8% with semaglutide vs 6.4% with liraglutide after 68 weeks was reported [27]

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Increased melanin production and tanning MT1 binds strongly to the melanocortin 1 receptor (MC1R), which is involved in the production of melanin, tyrosinase, and melanocyte [2, 3]