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D., Qu, H., Yang, Q

This result suggests that the brain has mechanisms that maintain a balance between the brakes and the accelerator to prevent brain activity from going out of control, a state we refer to as homeostasis."The researchers treated the mice with low doses of ketamine, an experimental antidepressant drug known to act by transiently blocking a major class of glutamate receptors in nerve cells

Its conceivable GLP-1 RAs could tick the first box indirectly (via weight loss) and the second box (if misused)

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Optional maintenance: once initial goals are met, tapering dose or frequency, with periodic checkins to sustain benefits

But that is not the whole picture