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Rarely, metformin can contribute to lactic acidosis, a serious condition more likely in settings such as severe kidney impairment, severe liver disease, heavy alcohol use, or acute illness with dehydration

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This can affect how your brain signals reproductive hormones, resulting in delayed ovulation

Lifestyle fixes can work for some people, studies show, but lots of people lose only modest amounts of weight or regain the pounds over timea process known as weight cycling that is itself linked to cardiovascular and metabolic health problems

Some metabolize the drug faster