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Bernetti C, Cea L, Buoso A, et al
The skin where you usually get injections has become thicker
Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease
Schedule: Daily subcutaneous injections for 812 weeks (extend to 16 weeks if desired), followed by a 24 week pause to resensitize receptors
Remarkably, beneficial effects have been observed across this 100-fold range, suggesting a wide therapeutic window where smaller doses remain biologically active
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