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However, it will not be easy, as patents for these medicines have not expired yet

Fixing these problems often reduces episodes

En la literatura, la magnitud de los efectos reportados tiende a crecer con el nmero de receptores, a cambio de un perfil gastrointestinal que depende de la dosis

The viability of renal tubular epithelial cells was markedly reduced and the number of dead cells, including those undergoing apoptosis, was significantly increased when the cells were treated for a prolonged period of time with high glucose concentrations

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Much of this comes from laboratory and animal work, so it is best read as a plausible pathway rather than a settled rule