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One More Fly in the Ointment One year after withdrawal of once-weekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained two-thirds of their prior weight loss, with similar changes in cardiometabolic variables

Semaglutide side effects also center on gastrointestinal issues, including nausea, vomiting, constipation, and diarrhea

Pregnant or breastfeeding women should also avoid it

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involving 407 individuals with obesity and knee OA, treatment with semaglutide resulted in significantly greater reductions in body weight ( 13.7% vs

Lifestyle intervention remains a cornerstone of effective weight management, in line with NICE obesity management guidance (CG189 and subsequent updates), regardless of pharmacological support