If you are pregnant, planning to become pregnant, or breastfeeding, discuss alternative weight management options with your healthcare provider
In addition, inclisiran (Leqvio), a small interfering RNA (siRNA) directed to PCSK9 mRNA, is FDA approved as adjunct to diet and exercise in adults with hypercholesterolemia, including HeFH
Both medications lead to muscle loss as part of the overall weight loss process
Side Effects Change in how much or how often you urinate, lower back or side pain, blood in your urine Unusual moods or behaviors, depression, thoughts of hurting yourself or others Blurred vision or any other change in vision Warnings Tell your doctor if you are breastfeeding, or if you have kidney disease, pancreas problems, diabetes, digestion problems (including gastroparesis), or a history of diabetic retinopathy or depression
You can maintain results after treatment by making intentional changes before, during, and after stopping the medication
A common approach involves gradually titrating the dose to minimize side effects while maximizing effectiveness
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