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10.1136/jmedgenet-2017-104704 109

Occasional vomiting may resolve without complications, but persistent vomiting increases the risk of dehydration and electrolyte imbalance

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A liver sample was fixed with 4% paraformaldehyde overnight at 4 C and embedded into paraffin

The elevation of cellular Ca 2+ activates several Ca 2+ -binding proteins, including calmodulin (CaM) complexes, and promotes the phosphorylation of CaMKII at a threonine residue (T286) in the autoinhibitory domain