The strongest results reported so far come from Phase 3 trials
Zhang H, He Y, Wang JX, Chen MH, Xu JJ, Jiang MH, Feng YL, Gu YF (2020) MiR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia
31 Since the 2021 review, one more RCT has been published that compared oral B12 alone, 25 g per day (form not reported), or with folate (800 g per day) versus no supplements for 6 months in patients with mild cognitive impairment
The considerations that matter before deciding: Compounded medication status is the most consequential variable
Cauda equina syndrome Central compression of nerve roots in the spinal canal below the level of the spinal cord
Nausea is the most common side-effect GLP-1 symptom, followed by vomiting, sour burps, heartburn and gastroparesis Side-Effect Profile of GLP-1s, from Worst to Best (% reflects estimated number of patients with GI side-effects) 50% Semaglutide (Ozempic, Rybelsus, Wegovy) 40% Tirzepatide (Saxenda, Mounjaro) 40% Liraglutide (Victoza, Saxenda) 30% Lixisenatide (Adlyxin USA, Lyxumia UK) 10% Dulaglutide (Trulicity) 10% Exenatide (Byetta, Bydureon) Wegovy, Mounjaro, and Saxenda FDA-approved for weight loss