how does glp 1 affect pancreas Cardiovascular, and brain effects of GLP-1 Beyond the pancreas: contrasting cardiometabolic

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It is also important to note that early-phase trials such as those conducted for retatrutide typically exclude participants with active major depressive disorder or suicidal ideation, which may limit the detection of psychiatric adverse events in the published data

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Importantly, initiation of GLP-1RA may decrease levothyroxine dose requirements in patients with hypothyroidism through weight loss, enhance levothyroxine absorption due to delayed gastrointestinal (GI) transit, and have direct effects on the hypothalamic-pituitary-thyroid axis [23,24,25,26,27,28,29], potentially increasing the risk of thyroid hormone over-replacement (i.e., iatrogenic hyperthyroidism)

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