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Oxidative stress markers begin shifting

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The hepatic processing of bilirubin is a highly coordinated system, with defects in any step potentially leading to hyperbilirubinemia or other metabolic disorders [23]

Similarly, there is risk in most studies of underreporting PDAC events due to ascertainment bias, because active surveillance is not typically performed in controlled trials or performed in routine clinical practice

Moderate caffeine intake (200 to 300 mg daily) can provide temporary relief, but it does not address the underlying causes