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Recent evidence suggests that their pleiotropic effectsbeyond glycemic control and weight lossinclude anti-inflammatory, immunomodulatory, and antioxidative effects, which may beneficially support various dermatologic conditions such as psoriasis, hidradenitis suppurativa, acanthosis nigricans, and Hailey-Hailey disease

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However, evidence supporting its efficacy is limited, and it may lead to an undesirable increase in blood pressure

Research in obese mice demonstrated that AOD-9604 increases beta-3 adrenergic receptor RNA expression, restoring levels comparable to those in lean mice

In addition, these polyps may become cancerous with time