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Nevertheless, two placebo-controlled crossover studies demonstrated that 2 months of folate supplementation improves endothelial function in hyperhomocysteinemic subjects by decreasing homocysteine levels (Bellamy et al, 1999

These studies, although confirming the concept of BT in humans, do not identify the mechanism whereby the bacteria are transported from lumen to the lymphatics

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There have also been case reports of birth defects in children with paternal exposure to isoretinoin

However, current models have important limitations, including species differences, incomplete representation of the ovarian microenvironment in vitro, and limited availability of human oocytes