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A novel, potent and selective PDE9 inhibitor (IMR-687) has been shown to increase levels of cGMP and HbF without signs of myelosuppression in cell lines of patients with SCD

10.3389/fped.2022.791815 73 XiaoJ

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Fluorescence methods, while also sensitive, may be affected by sample turbidity or color that interfere with light absorption and emission, but often provide better selectivity for specific antioxidants due to tunable fluorophore properties (Krzymiski et al., 2019)