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Studies on GLP-1 medications highlight factors that negatively impact nutritional health and well-being, including loss of lean body weight (muscle mass), gastrointestinal side effects, reduced intake of protein, fiber and essential micronutrients, as well as significant decreases in daily calorie intake by as much as 40-50%
But the gap in clinical outcomes between the two classes may narrow as insulin technology catches up with the incretin-based revolution
In good agreement with the above-described processes, carnitine seems to be involved also in insulin sensitivity (Figure 1): it was observed that the muscle accumulation of fatty acyl-CoA derivatives or acyl metabolites inhibits both insulin signaling and glucose oxidation (Pietrocola et al., 2015
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