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SIRT1 and oxidative stress Brain tissue has superior oxygen metabolism with low antioxidant capacity resulting in oxidative stress which damages DNs in the SN (Parga et al

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The authors acknowledge that their interpretation is limited by inadequate knowledge of the function of the ALA alleles of GPx-1 gene

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Adjunctive approaches involving topical calcineurin inhibitors or corticosteroids in conjunction with phototherapy have yielded improved regimentation outcomes [209, 210], while emerging combinations with antioxidants and laser therapies offer additional therapeutic potential, albeit with limited clinical data to date [211]

Addressing these issues promptly supports recovery and prevents complications