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Insulin Sensitivity and Blood Sugar Control: For individuals with type 2 diabetes, semaglutide also stimulates insulin release when blood sugar levels are high and suppresses glucagon secretion, leading to improved glycemic control

Across pivotal Phase 3 trials, mean weight loss has scaled with the number of receptors a compound engages: semaglu tide (single agonist) at 14.9%, tirzepatide (dual agonist) at 22.5%, and retatrutide (triple agonist) at 28.3% over 80 weeks

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Although there is no known interaction between Wegovy and Contrave or Wellbutrin, all three medications suppress appetite

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