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Human sleep studies were conducted mainly during the 1980s and early 1990s, but they involved small groups, inconsistent methods and mixed results

This became evident when HSL-deficient mice were produced and shown to efficiently hydrolyze TG and they do not accumulate TG in either adipose or nonadipose tissues, but they do accumulate large amounts of DGs in many tissues

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Oral Clefts In the NAAED Pregnancy Registry, the prevalence of oral clefts among topiramate-exposed infants (1.4%) was higher than the prevalence in infants exposed to a reference AED (0.3%) or the prevalence in infants with mothers without epilepsy and without exposure to AEDs (0.11%)