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Choosing Between Semaglutide, Tirzepatide, and Dual-Compound Options Semaglutide injection (at $189/mo month-to-month, or from $149/mo on the 6-month plan) and tirzepatide injection (starting at $289/mo (or $249/mo on the 6-month plan)) both demonstrate strong efficacy in randomized trials, but tirzepatidea dual GLP-1 and GIP receptor agonistproduces slightly greater weight loss on average

[PMC free article: PMC6375548] [PubMed: 30763313] 14

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For example, chemogenetic inhibition of VTA dopamine neurons prevented the ability of a priming injection of cocaine and stress to reinstate drug seeking in cocaine-experienced rats 59