They should be carefully administered to patients with risks of hypovolemia (older age, cardiovascular diseases, treatment with diuretics, liver cirrhosis with circulatory dysfunction)
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Suppression of ferroptosis by vitamin a or radical-trapping antioxidants is essential for neuronal development
Important next steps include exploratory early-phase trials to establish CNS penetrance, target engagement (CSF GLP-1/IGF-1), and downstream biomarkers such as MCP-1 and NfL, before larger efficacy studies can be justified
Localized increase of chemokines in the lumen of human cerebral aneurysms
In general, these methods have yielded promising results for increasing the bioavailability of curcumin, thereby enhancing its therapeutic effects across a wide range of diseases