A recent study has examined the effect of cobalamin supplementation on the outcomes of treatment for feline patients with severe cobalamin deficiency and histories suggesting chronic gastrointestinal disease.5 In this study, serum concentrations of methylmalonic acid normalized following parenteral cobalamin supplementation, indicating that cobalamin deficiency was the cause of the high methylmalonic acid in serum
In animal and preclinical studies, it is associated with tissue-protective effects, modulation of inflammatory signaling, and support of angiogenesis and tendon-to-bone healing pathways
This drop closely correlates with the well-known reduction in regenerative capacity seen across multiple organ systems as we age
Primary Handling Editor: Alfredo Gimnez-Cassina, in collaboration with the Nature Metabolism team
Her eczema had spread to the soles of her feet and even though she was only in her early 20s she was hobbling around like an old lady
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