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Additionally, FOXO transcription factors have recently been implicated in tumorigenesis: in fact, rhabdomyosarcomas present FOXO genes with a high percentage of mutations that render them insensitive to inhibition by AKT signaling 65

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Chromatin immunoprecipitation Chromatin immunoprecipitation (ChIP) was performed as described previously (Leon et al., 2021)

We selected several additional mutants ( rim11 , ksp1 , and cek2 ) for further validation (Fig

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