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(2013) established an in vitro model of insulin resistance and diabetes using the pancreatic INS-1E -cell line

The FDA recommends you switch to non-oral alternatives for a month after starting the medication and every time you go up in dose to be safe

Patients who specifically require FDA-approved products should clarify this with their evaluating clinician

For example, cardiology guidelines already emphasize overall cardiovascular risk rather than relying solely on individual markers like cholesterol levels

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a non-oral method or additional barrier contraception during initiation and escalation may be advisable until more data are available